Mouse models of psoriasis and their relevance

Psoriasis is an inflammatory skin disorder that includes dynamic interactions between the immune system and skin and is clinically characterized by keratinocyte proliferation and distinct inflammatory cell infiltrates. Cross‐talk between keratinocytes and immunocytes is essential for the development...

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Veröffentlicht in:Journal of dermatology 2018-03, Vol.45 (3), p.252-263
Hauptverfasser: Nakajima, Kimiko, Sano, Shigetoshi
Format: Artikel
Sprache:eng
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Zusammenfassung:Psoriasis is an inflammatory skin disorder that includes dynamic interactions between the immune system and skin and is clinically characterized by keratinocyte proliferation and distinct inflammatory cell infiltrates. Cross‐talk between keratinocytes and immunocytes is essential for the development of psoriasis given that it mediates the production of cytokines, chemokines and growth factors. To resolve the pathogenesis of psoriasis, numerous experimental animal models have been generated. In this review, we discuss recent findings from mouse models, their relevancy to psoriasis and use, including the discovery of new therapies.
ISSN:0385-2407
1346-8138
DOI:10.1111/1346-8138.14112