Comparative Study of Toxicity of Alkoxyamines In Vitro and In Vivo

Effect of alkoxyamines on normal and tumor cells was studied in vitro and in vivo . In vitro experiments showed that alkoxyamines produce a dose-dependent toxic effect on cells of human breast tumor MCF7 line. Transplantation of Krebs-2 ascites carcinoma cells preincubated with alkoxyamines to mice did not induce tumor growth. An opposite effect was observed in normal mouse cells: functional activity of peritoneal macrophages increased. The possibility of using alkoxyamines as theranostic agents is discussed.