Dietary polyunsaturated fatty acids and sex interact to determine myocardial membrane fatty acid composition

Dietary polyunsaturated fatty acids and sex interact to determine myocardial membrane fatty acid composition

Background - Clinical and experimental studies have shown that dietary polyunsaturated fatty acids (PUFA) modulate cardiac function under pathological conditions, and that this is, at least in part due to modulation of the membrane fatty acid composition. Outcomes - Dietary FO was associated with a...

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Veröffentlicht in:Asia Pacific journal of clinical nutrition 2008-12, Vol.17, p.S117-S117
Hauptverfasser: Huggins, C E, McLennan, P L, Theiss, M L, Pepe, S, Delbridge, L M D
Format: Artikel
Sprache:eng
Schlagworte:
Diet
Fatty acids
Females
Fish oils
Rodents
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Zusammenfassung:Background - Clinical and experimental studies have shown that dietary polyunsaturated fatty acids (PUFA) modulate cardiac function under pathological conditions, and that this is, at least in part due to modulation of the membrane fatty acid composition. Outcomes - Dietary FO was associated with a smaller hypertrophic index (heart mass normalized to body mass) in hearts of males (mean ± SEM, TG CTR/FO 5.0 ± 0.3 vs 4.4 ± 0.2 mg/g, P0.05), and this was coupled with a greater myocardial membrane omega-3: omega-6 PUFA ratio in male mice compared to female mice (TG FO 5.8 4± 0.14 vs 5.42 ± 0.18, P
ISSN:0964-7058
1440-6047