18F-Sodium Fluoride Uptake in Abdominal Aortic Aneurysms: The SoFIA3Study

Background Fluorine-18-sodium fluoride (18F-NaF) uptake is a marker of active vascular calcification associated with high-risk atherosclerotic plaque. Objectives In patients with abdominal aortic aneurysm (AAA), the authors assessed whether18F-NaF positron emission tomography (PET) and computed tomo...

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Veröffentlicht in:	Journal of the American College of Cardiology 2018-02, Vol.71 (5), p.513
Hauptverfasser:	sythe, Rachael O, Dweck, Marc R, McBride, Olivia MB, Vesey, Alex T, Semple, Scott I, Shah, Anoop SV, Adamson, Philip D, Wallace, William A, Kaczynski, Jakub, Ho, Weiyang, van Beek, Edwin JR, Gray, Calum D, Fletcher, Alison, Lucatelli, Christophe, Marin, Aleksander, Burns, Paul, Tambyraja, Andrew, Roderick TA Chalmers, Weir, Graeme, Mitchard, Neil, Tavares, Adriana, Robson, Jennifer MJ, Newby, David E
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen Aneurysms Angiography Aorta Aortic aneurysms Arteriosclerosis Atherosclerosis Biomechanics Calcification Calcification (ectopic) Calcium Cardiology Clinical trials Committees Computed tomography Control methods Coronary vessels Emission analysis Family medical history Fluorides Fluorine Fluorine isotopes Histology Inflammation Laboratories Magnetic resonance imaging Maintenance Medical imaging NMR Nuclear magnetic resonance Patients Positron emission Positron emission tomography Repair Rupture Rupturing Sodium Sodium fluoride Surgery Surveillance Ultrasound
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Zusammenfassung:	Background Fluorine-18-sodium fluoride (18F-NaF) uptake is a marker of active vascular calcification associated with high-risk atherosclerotic plaque. Objectives In patients with abdominal aortic aneurysm (AAA), the authors assessed whether18F-NaF positron emission tomography (PET) and computed tomography (CT) predicts AAA growth and clinical outcomes. Methods In prospective case-control (n = 20 per group) and longitudinal cohort (n = 72) studies, patients with AAA (aortic diameter >40 mm) and control subjects (aortic diameter
ISSN:	0735-1097 1558-3597
DOI:	10.1016/j.jacc.2017.11.053