In Vivo Mast Cell Activation by the MRGPRX2 Receptor Ligands

In Vivo Mast Cell Activation by the MRGPRX2 Receptor Ligands

While in vitro studies show MRGPRX2 activation by substance P, VIP, compound 48/80 and therapeutic drugs associated with pseudoallergic reactions, no human studies of MRGPRX2 activation have been performed. Methods Healthy controls (n=9) and urticaria subjects (n=2) underwent serial intradermal skin...

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Veröffentlicht in:Journal of allergy and clinical immunology 2018-02, Vol.141 (2), p.AB35-AB35
Hauptverfasser: Shtessel, Maria, Oliver, Eric T., Chichester, Kristin L., Saini, Sarbjit Singh
Format: Artikel
Sprache:eng
Schlagworte:
Cell activation
Compound 48/80
Ligands
Skin tests
Substance P
Titration
Urticaria
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Zusammenfassung:While in vitro studies show MRGPRX2 activation by substance P, VIP, compound 48/80 and therapeutic drugs associated with pseudoallergic reactions, no human studies of MRGPRX2 activation have been performed. Methods Healthy controls (n=9) and urticaria subjects (n=2) underwent serial intradermal skin titration testing with icatibant and atracurium (1 x 10-6 to 1 x 10-1 mg/ml) insulin and saline as negative controls, and histamine serial titration.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2017.12.113