Immunological changes induced by Pru p 3-glycodendrimers

Immunological changes induced by Pru p 3-glycodendrimers

Rationale Glycodendrimers functionalized with mannose are promising structures to enhance allergen interaction with antigen presenting cells via C-type lectin receptors and modulate the immune response. Responses were analysed in peach allergic patients and healthy controls, by studying monocyte-der...

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Veröffentlicht in:Journal of allergy and clinical immunology 2018-02, Vol.141 (2), p.AB124-AB124
Hauptverfasser: Palomares, Maria Francisca, Gomez, Francisca, Mascaraque, Ainhoa, Bogas, Gador, Ramos-Soriano, Javier, Rodríguez, Maria José, Torres Jaén, Maria Jose, Rojo, Javier, Mayorga, Cristobalina
Format: Artikel
Sprache:eng
Schlagworte:
Antigen-presenting cells
Cell growth
Dendritic cells
Food allergies
Immunology
Monocytes
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Zusammenfassung:Rationale Glycodendrimers functionalized with mannose are promising structures to enhance allergen interaction with antigen presenting cells via C-type lectin receptors and modulate the immune response. Responses were analysed in peach allergic patients and healthy controls, by studying monocyte-derived-dendritic cell (moDC) maturation and interaction using blocking DC-Sign (αCD209) and mannose (αCD206) receptors, and lymphocyte proliferation, by flow cytometry.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2017.12.394