Mitochondrial Oxidative Stress Is Associated With Age-Related Glandular Remodeling And Nasal Polyp Formation

Mitochondrial Oxidative Stress Is Associated With Age-Related Glandular Remodeling And Nasal Polyp Formation

Methods NP and uncinate process tissues from young (18-49), mature (50-64), and older (>=65) adults with NP and age-matched healthy controls were examined with H&E and periodic acid-Schiff (PAS) staining. Results In healthy controls, there was a dramatic age-related decrease of serous submuco...

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Veröffentlicht in:Journal of allergy and clinical immunology 2018-02, Vol.141 (2), p.AB203-AB203
Hauptverfasser: Jo, Ara, Casale, Thomas B., Suh, Lydia A., Carter, Roderick G., Conley, David B., Kern, Robert C., Tan, Bruce K., Peters, Anju T., Grammer, Leslie C., Schleimer, Robert P., Cho, Seong Ho
Format: Artikel
Sprache:eng
Schlagworte:
Age
Mitochondria
Oxidative stress
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Zusammenfassung:Methods NP and uncinate process tissues from young (18-49), mature (50-64), and older (>=65) adults with NP and age-matched healthy controls were examined with H&E and periodic acid-Schiff (PAS) staining. Results In healthy controls, there was a dramatic age-related decrease of serous submucosal glandular cells and a relative increase of PAS-stained mucous cells, together with submucosal glandular metaplasia.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2017.12.642