The Leukotriene E4Receptor, CysLT3r Regulates Airway Chemosensory Brush Cell Expansion

The Leukotriene E4Receptor, CysLT3r Regulates Airway Chemosensory Brush Cell Expansion

Rationale The receptor for the stable cysteinyl leukotriene (cysLT) LTE4, CysLT3R, is an upper airway epithelial cell (EpC) receptor that mediates mucin release in the nose in response to the mold aeroallergen, Alternaria alternata. Conclusions CysLT3R is activated by endogenously generated lipid li...

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Veröffentlicht in:Journal of allergy and clinical immunology 2018-02, Vol.141 (2), p.AB400
Hauptverfasser: Lora Georgieva Bankova, Yoshimoto, Eri, Giannetti, Matthew P, Kanaoka, Yoshihide, Austen, K Frank, Barrett, Nora A
Format: Artikel
Sprache:eng
Schlagworte:
Alternaria alternata
Chemoreception
Cladosporium herbarum
Respiratory tract
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Zusammenfassung:Rationale The receptor for the stable cysteinyl leukotriene (cysLT) LTE4, CysLT3R, is an upper airway epithelial cell (EpC) receptor that mediates mucin release in the nose in response to the mold aeroallergen, Alternaria alternata. Conclusions CysLT3R is activated by endogenously generated lipid ligand LTE4 and regulates airway BrC number and sentinel function through and IL-25 signaling pathway.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2017.12.940