CD4+ and CD8+CD60+CD45RO+IL-4+IFNγ- T Cells Expressing Receptors for Complement Split Product (CSP) C3a, but Not C5a, Are Increased in Blood of Serum IgE+, Compared With Serum IgE- Adults

CD4+ and CD8+CD60+CD45RO+IL-4+IFNγ- T Cells Expressing Receptors for Complement Split Product (CSP) C3a, but Not C5a, Are Increased in Blood of Serum IgE+, Compared With Serum IgE- Adults

Methods CD4+CD3+ and CD8+CD60+CD45RO±CD45RA±IL-4±IFNγ± T cells in blood of serum IgE+ (fluoroimmunoassay) ragweed sensitized (RS) and IgE- nonallergic humans expressing receptors for CSP C3a and C5a (CD88) (n=2-3/group) were determined by flow cytometry. Conclusions The presence of receptors for C3a...

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Veröffentlicht in:Journal of allergy and clinical immunology 2018-02, Vol.141 (2), p.AB116-AB116
Hauptverfasser: DeGregorio, Lucius, Morello, Timothy D., Chice, Seto M., Nowakowski, Maja, Saadia, Tehila A., Smith-Norowitz, Tamar A., Joks, Rauno, Durkin, Helen G.
Format: Artikel
Sprache:eng
Schlagworte:
CD4 antigen
CD8 antigen
Complement component C3a
Complement component C5a
Interleukin 4
Lymphocytes
Lymphocytes T
γ-Interferon
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Zusammenfassung:Methods CD4+CD3+ and CD8+CD60+CD45RO±CD45RA±IL-4±IFNγ± T cells in blood of serum IgE+ (fluoroimmunoassay) ragweed sensitized (RS) and IgE- nonallergic humans expressing receptors for CSP C3a and C5a (CD88) (n=2-3/group) were determined by flow cytometry. Conclusions The presence of receptors for C3a on CD4+ and CD8+CD60+CD45RO+ IL-4+ T cells required for induction of ragweed specific memory IgE responses suggests that C3a may play an important role in induction of these responses.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2017.12.368