Dysbiosis of intestinal microbiota increases mortality to a respiratory viral infection through elevated production of IFNγ by innate lymphoid cells

Rationale Using a normally non-lethal dose of Sendai virus (SeV), we demonstrated that alteration of just the intestinal microbiota led to a marked and significant increase in mortality. Conclusions ILCs, while being a small population, may represent the cell type that is responsible for increased pulmonary IFNγ during a respiratory viral infection after disruption of gastrointestinal microbiota.