Expression of the Steroidogenic Enzyme, CYP11A1, Identifies Peanut-Allergic Children at Risk for Developing Life-Threatening Anaphylaxis

Expression of the Steroidogenic Enzyme, CYP11A1, Identifies Peanut-Allergic Children at Risk for Developing Life-Threatening Anaphylaxis

Cyp11a1 expression levels were monitored by real-time PCR and protein expression in cells was detected by flow cytometry and immunocytochemistry staining. In these patients, there was a significant correlation between Cyp11a1 mRNA expression levels and IL-13 mRNA and protein levels.

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Veröffentlicht in:Journal of allergy and clinical immunology 2018-02, Vol.141 (2), p.AB201-AB201
Hauptverfasser: Wang, Meiqin, Lanser, Bruce J., Santos, Carah B., Bendelja, Kreso, Fish, Jennifer, Esterl, Elizabeth A., Abbott, Jordan, Gelfand, Erwin W.
Format: Artikel
Sprache:eng
Schlagworte:
Anaphylaxis
Children
Enzymes
Food allergies
Proteins
Rodents
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Zusammenfassung:Cyp11a1 expression levels were monitored by real-time PCR and protein expression in cells was detected by flow cytometry and immunocytochemistry staining. In these patients, there was a significant correlation between Cyp11a1 mRNA expression levels and IL-13 mRNA and protein levels.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2017.12.636