A Role for B Cells in Organic Dust Induced Lung Injury

A Role for B Cells in Organic Dust Induced Lung Injury

Serum IgG responses, anti-citrullinated protein antibody (ACPA), and anti-malondialdehyde-acetaldehyde (MAA) autoantibody responses were increased in ODE treated WT mice vs. saline control. Conclusions Agriculture organic dust induced lung injury is dependent upon B cells, and this exposure induces...

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Veröffentlicht in:Journal of allergy and clinical immunology 2018-02, Vol.141 (2), p.AB198-AB198
Hauptverfasser: Poole, Jill A., Mikuls, Ted R., Duryee, Michael J., Warren, Kristi J.J., Wyatt, Todd A., Nelson, Amy J., Romberger, Debra J., West, William W., Thiele, Geoffrey
Format: Artikel
Sprache:eng
Schlagworte:
Immune response
Immunoglobulins
Lungs
Lymphocytes B
Organic farming
Proteins
Rodents
T cell receptors
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Zusammenfassung:Serum IgG responses, anti-citrullinated protein antibody (ACPA), and anti-malondialdehyde-acetaldehyde (MAA) autoantibody responses were increased in ODE treated WT mice vs. saline control. Conclusions Agriculture organic dust induced lung injury is dependent upon B cells, and this exposure induces autoreactive immune responses to citrullinated and MAA-modified proteins implicated in the systemic autoimmune pathogenesis.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2017.12.628