Environmental exposure to Staphylococcus aureus and SEB are associated with asthma symptoms and worse lung function among low-income, urban children with asthma

Environmental exposure to Staphylococcus aureus and SEB are associated with asthma symptoms and worse lung function among low-income, urban children with asthma

Rationale Staphylococcus aureus (SA) nasal colonization has been linked to asthma symptoms, but whether environmental exposures to SA or staphylococcal enterotoxins (SEs), independent of colonization, contribute to asthma morbidity is unclear. Methods We measured SA (femB) and SEA-C genes in home du...

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Veröffentlicht in:Journal of allergy and clinical immunology 2018-02, Vol.141 (2), p.AB193-AB193
Hauptverfasser: Davis, Meghan F., Ludwig, Shanna, Josephs-Spaulding, Jonathan, Dalton, Kathryn, Newman, Michelle, Balcer-Whaley, Susan L., Peng, Roger, Keet, Corinne, McCormack, Meredith C., Matsui, Elizabeth C.
Format: Artikel
Sprache:eng
Schlagworte:
Asthma
Children
Genes
Lungs
Morbidity
Respiratory function
Staphylococcus aureus
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Zusammenfassung:Rationale Staphylococcus aureus (SA) nasal colonization has been linked to asthma symptoms, but whether environmental exposures to SA or staphylococcal enterotoxins (SEs), independent of colonization, contribute to asthma morbidity is unclear. Methods We measured SA (femB) and SEA-C genes in home dust using real-time PCR and cultured nasal swabs in an ongoing cohort (NCT02251379) of 5-17yo African-American children with asthma.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2017.12.612