High consistency in allergen composition of SQ house dust mite (HDM) tablet for sublingual immunotherapy (SLIT)

High consistency in allergen composition of SQ house dust mite (HDM) tablet for sublingual immunotherapy (SLIT)

Quality control included total IgE binding capacity by Centaur assay, major allergen determination by radial immuno diffusion; protein and antigen profile by SDS-PAGE and crossed immunoelectrophoresis, respectively. Conclusions Variation in allergen content was observed in the source material, but f...

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Veröffentlicht in:Journal of allergy and clinical immunology 2018-02, Vol.141 (2), p.AB274-AB274
Hauptverfasser: Henmar, Helene, Mikles, Andrew, Grosch, Karin, Larsen, Jorgen N.
Format: Artikel
Sprache:eng
Schlagworte:
Allergens
Antigens
Fractionation
Gel electrophoresis
House dust
Immunotherapy
Mites
Oral administration
Sodium lauryl sulfate
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Zusammenfassung:Quality control included total IgE binding capacity by Centaur assay, major allergen determination by radial immuno diffusion; protein and antigen profile by SDS-PAGE and crossed immunoelectrophoresis, respectively. Conclusions Variation in allergen content was observed in the source material, but fractionation enabled a process resulting in a highly standardised composition of the SQ-HDM SLIT-tablet.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2017.12.873