Risk Factors for Anaphylactoid Reaction to Low Osmolar Contrast During Cardiac Catheterization

Rationale Beta blockers(BB) have been associated with increased risk for severe anaphylactoid reaction(AR) from contrast media(CM); however, this was shown with intravenous CM(Arch Intern Med 1993;153:2033), prior to widespread use of low osmolar contrast media(LOCM), ACE inhibitors(ACE-I) and cardioselective BB. There were no significant differences in age (61.3% vs 61.5%), gender (63% vs 64% male), CVD rate (78% vs 93%), exposure to BB (46% vs 51%, cardioselective: 81% vs 80%) and ACE-I (37.0% vs 37.2%) in cases vs. controls.