Consistent composition and potency of freeze dried tablets for sublingual immunotherapy

Consistent composition and potency of freeze dried tablets for sublingual immunotherapy

Release kinetics of individual allergen components from source materials differ, and the production process must be optimised individually for every source material in order to secure consistent composition and potency of the final drug product. Methods Aqueous extraction of grass and ragweed pollen...

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Veröffentlicht in:Journal of allergy and clinical immunology 2018-02, Vol.141 (2), p.AB171-AB171
Hauptverfasser: Henmar, Helene, Sønderkær, Susanne, Nørby, Pernille H., Christensen, Lars H., Larsen, Jorgen N.
Format: Artikel
Sprache:eng
Schlagworte:
Freeze drying
Immunotherapy
Oral administration
Tablets
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Beschreibung
Zusammenfassung:Release kinetics of individual allergen components from source materials differ, and the production process must be optimised individually for every source material in order to secure consistent composition and potency of the final drug product. Methods Aqueous extraction of grass and ragweed pollen as well as house dust mite (HDM) particles was performed under chemical conditions resembling the conditions on the airway mucosa.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2017.12.545