Efficient Synthesis of Chiral Indolines using an Imine Reductase from Paenibacillus lactis

Efficient Synthesis of Chiral Indolines using an Imine Reductase from Paenibacillus lactis

An enzymatic process for the efficient asymmetric reduction of 3H‐indoles as well as 3H‐indole iodides was developed for the first time. Using a new imine reductase identified from Paenibacillus lactis (PlSIR), various chiral indolines were facilely synthesized in good yields and excellent enantiopu...

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Veröffentlicht in:Advanced synthesis & catalysis 2015-05, Vol.357 (8), p.1692-1696
Hauptverfasser: Li, Hao, Luan, Zheng-Jiao, Zheng, Gao-Wei, Xu, Jian-He
Format: Artikel
Sprache:eng
Schlagworte:
3H-indoles
asymmetric hydrogenation
biocatalysis
chiral indolines
Heterocyclic compounds
imine reductase
Indoles
Iodides
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Zusammenfassung:An enzymatic process for the efficient asymmetric reduction of 3H‐indoles as well as 3H‐indole iodides was developed for the first time. Using a new imine reductase identified from Paenibacillus lactis (PlSIR), various chiral indolines were facilely synthesized in good yields and excellent enantiopurities (up to >99% ee) under mild reaction conditions.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201500160