Effects of stress on wound healing and its possible mechanism

Wound healing is a complex and orderly biological process. Any factor hindering its smooth progress will impact the wound healing. A large number of clinical and experimental studies suggested that stress played a very important role in the process and outcome of wound healing. Moderate stress was not only a harmless factor on wound healing, but also beneficial to promote the wound healing. However, excessive stress will certainly affect the speed and quality of wound healing. Although it was clear that the severity of stress positively correlated with the levels of stress hormones, but the exact mechanisms and influential factors remain unclear. The present paper will discuss the possible mechanisms of stress in affecting the wound healing by retrieving relevant domestic and foreign literature, so as to provide a reference for accelerating the rate and improving the quality of wound healing by regulation and control of stress.