Effects of puerarin combined with edaravone on inhalation lung injury induced by black gunpowder smog in rats
Objective To explore the protective effects of puerarin combined with edaravone on inhalation lung injury induced by black gunpowder smog in rats. Methods Forty healthy male Wistar rats were randomly divided into normal control group (group N), inhalation group (group X), puerarin group (group P), e...
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| Veröffentlicht in: | Jie fang jun yi xue za zhi 2015-01, Vol.40 (1), p.66 |
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| container_title | Jie fang jun yi xue za zhi |
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| creator | Zheng-guan, WANG Rui-bing, LI Shu-min, XU Yu-ni, GUO Wen-yan, CHEN Yi-hong, CHEN Cheng-bin, WANG |
| description | Objective To explore the protective effects of puerarin combined with edaravone on inhalation lung injury induced by black gunpowder smog in rats. Methods Forty healthy male Wistar rats were randomly divided into normal control group (group N), inhalation group (group X), puerarin group (group P), edaravone group (group E) and edaravone combined with puerarin group (group L), with 8 rats in each group. Rat model of inhalation lung injury was reproduced by a self-made smoke generator. Rats in group E were given intraperitoneal injections of edaravone (9 mg/kg) at 30 minutes and 1 day after modeling (twice totally). Rats in group P were given intraperitoneal injections of puerarin (100 mg/kg) at 30 minutes and 1, 2, 3, 4, 5 days after modeling (6 times totally). Rats in group L were treated the way of both group E and P. The rats in group N and group X were given intraperitoneal injections of normal saline (12 ml/kg) at the time-points above. The animals were sacrificed 6 days after modeling, and the blood samp |
| doi_str_mv | 10.11855/j.issn.0577-7402.2015.01.15 |
| format | Article |
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Methods Forty healthy male Wistar rats were randomly divided into normal control group (group N), inhalation group (group X), puerarin group (group P), edaravone group (group E) and edaravone combined with puerarin group (group L), with 8 rats in each group. Rat model of inhalation lung injury was reproduced by a self-made smoke generator. Rats in group E were given intraperitoneal injections of edaravone (9 mg/kg) at 30 minutes and 1 day after modeling (twice totally). Rats in group P were given intraperitoneal injections of puerarin (100 mg/kg) at 30 minutes and 1, 2, 3, 4, 5 days after modeling (6 times totally). Rats in group L were treated the way of both group E and P. The rats in group N and group X were given intraperitoneal injections of normal saline (12 ml/kg) at the time-points above. 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Methods Forty healthy male Wistar rats were randomly divided into normal control group (group N), inhalation group (group X), puerarin group (group P), edaravone group (group E) and edaravone combined with puerarin group (group L), with 8 rats in each group. Rat model of inhalation lung injury was reproduced by a self-made smoke generator. Rats in group E were given intraperitoneal injections of edaravone (9 mg/kg) at 30 minutes and 1 day after modeling (twice totally). Rats in group P were given intraperitoneal injections of puerarin (100 mg/kg) at 30 minutes and 1, 2, 3, 4, 5 days after modeling (6 times totally). Rats in group L were treated the way of both group E and P. The rats in group N and group X were given intraperitoneal injections of normal saline (12 ml/kg) at the time-points above. 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| subjects | Cytokines Proteins Rodents Smog Tumor necrosis factor-TNF |
| title | Effects of puerarin combined with edaravone on inhalation lung injury induced by black gunpowder smog in rats |
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