Synthesis and Characterization of a Series of Orthogonally Protected l-Carnosine Derivatives

l -Carnosine (β-alanyl- l -histidine) is an endogenous dipeptide that has been recognized for its broad spectrum of beneficial biological activities. However, the therapeutic utility of molecule has been hampered by its instability in human plasma (half-life in human serum

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of peptide research and therapeutics 2019-03, Vol.25 (1), p.379-390
Hauptverfasser:	El-Dakdouki, Mohammad H., Daouk, Nadine, Abdallah, Hiba
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Animal Anatomy Biochemistry Biological activity Biological properties Biomedical and Life Sciences C-Terminus Carnosine Chemical synthesis Drug therapy Histidine Histology Imidazole Life Sciences Mass spectroscopy Molecular Medicine Morphology N-Terminus NMR Nuclear magnetic resonance Peptides Pharmaceutical Sciences/Technology Pharmacology/Toxicology Phenylalanine Polymer Sciences Senile plaques β-Amyloid
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	l -Carnosine (β-alanyl- l -histidine) is an endogenous dipeptide that has been recognized for its broad spectrum of beneficial biological activities. However, the therapeutic utility of molecule has been hampered by its instability in human plasma (half-life in human serum
ISSN:	1573-3149 1573-3904
DOI:	10.1007/s10989-018-9680-2