New series of 4(3H)-quinazolinone derivatives: syntheses and evaluation of antitumor and antiviral activities
New series of 3-(3-trifluoromethylphenyl)-6-iodo-4(3 H )-quinazolinone derivatives bearing thiosemicarbazones, pyrazoles, azomethine moieties at C-2 were synthesized. The obtained products were screened for their expected anticancer activity against; human liver cancer cell line (HepG2), breast canc...
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| Veröffentlicht in: | Medicinal chemistry research 2018-02, Vol.27 (2), p.571-582 |
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| container_title | Medicinal chemistry research |
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| creator | Abbas, Samir Y. El-Bayouki, Khairy A. M. Basyouni, Wahid M. Mostafa, Eslam A. |
| description | New series of 3-(3-trifluoromethylphenyl)-6-iodo-4(3
H
)-quinazolinone derivatives bearing thiosemicarbazones, pyrazoles, azomethine moieties at C-2 were synthesized. The obtained products were screened for their expected anticancer activity against; human liver cancer cell line (HepG2), breast cancer cell line (MCF-7) and human lung adenocarcinoma epithelial cell line (A549) tumor cell lines. Cytotoxicity of the synthesized compounds showed good IC
50
for some products in comparison with the standard drug, doxorubicin. On the other hand, antiviral activity of the synthesized products against H
5
N
1
showed moderate to weak activity compared to Zanamivir reference drug. |
| doi_str_mv | 10.1007/s00044-017-2083-7 |
| format | Article |
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H
)-quinazolinone derivatives bearing thiosemicarbazones, pyrazoles, azomethine moieties at C-2 were synthesized. The obtained products were screened for their expected anticancer activity against; human liver cancer cell line (HepG2), breast cancer cell line (MCF-7) and human lung adenocarcinoma epithelial cell line (A549) tumor cell lines. Cytotoxicity of the synthesized compounds showed good IC
50
for some products in comparison with the standard drug, doxorubicin. On the other hand, antiviral activity of the synthesized products against H
5
N
1
showed moderate to weak activity compared to Zanamivir reference drug.</description><identifier>ISSN: 1054-2523</identifier><identifier>EISSN: 1554-8120</identifier><identifier>DOI: 10.1007/s00044-017-2083-7</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adenocarcinoma ; Anticancer properties ; Antitumor activity ; Antiviral activity ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Breast cancer ; Cancer ; Cell Biology ; Cytotoxicity ; Derivatives ; Doxorubicin ; Epithelial cells ; Hepatocytes ; Liver ; Liver cancer ; Original Research ; Pharmacology/Toxicology ; Pyrazoles ; Quinazolinone ; Synthesis ; Toxicity ; Tumor cell lines ; Zanamivir</subject><ispartof>Medicinal chemistry research, 2018-02, Vol.27 (2), p.571-582</ispartof><rights>Springer Science+Business Media, LLC 2017</rights><rights>Copyright Springer Science & Business Media 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-dad27733f7c4dcb05af47dda1c656fdc2c70dd3ecf5bc5e312af224706c7cf9b3</citedby><cites>FETCH-LOGICAL-c316t-dad27733f7c4dcb05af47dda1c656fdc2c70dd3ecf5bc5e312af224706c7cf9b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00044-017-2083-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00044-017-2083-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids></links><search><creatorcontrib>Abbas, Samir Y.</creatorcontrib><creatorcontrib>El-Bayouki, Khairy A. M.</creatorcontrib><creatorcontrib>Basyouni, Wahid M.</creatorcontrib><creatorcontrib>Mostafa, Eslam A.</creatorcontrib><title>New series of 4(3H)-quinazolinone derivatives: syntheses and evaluation of antitumor and antiviral activities</title><title>Medicinal chemistry research</title><addtitle>Med Chem Res</addtitle><description>New series of 3-(3-trifluoromethylphenyl)-6-iodo-4(3
H
)-quinazolinone derivatives bearing thiosemicarbazones, pyrazoles, azomethine moieties at C-2 were synthesized. The obtained products were screened for their expected anticancer activity against; human liver cancer cell line (HepG2), breast cancer cell line (MCF-7) and human lung adenocarcinoma epithelial cell line (A549) tumor cell lines. Cytotoxicity of the synthesized compounds showed good IC
50
for some products in comparison with the standard drug, doxorubicin. On the other hand, antiviral activity of the synthesized products against H
5
N
1
showed moderate to weak activity compared to Zanamivir reference drug.</description><subject>Adenocarcinoma</subject><subject>Anticancer properties</subject><subject>Antitumor activity</subject><subject>Antiviral activity</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Cell Biology</subject><subject>Cytotoxicity</subject><subject>Derivatives</subject><subject>Doxorubicin</subject><subject>Epithelial cells</subject><subject>Hepatocytes</subject><subject>Liver</subject><subject>Liver cancer</subject><subject>Original Research</subject><subject>Pharmacology/Toxicology</subject><subject>Pyrazoles</subject><subject>Quinazolinone</subject><subject>Synthesis</subject><subject>Toxicity</subject><subject>Tumor cell lines</subject><subject>Zanamivir</subject><issn>1054-2523</issn><issn>1554-8120</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kEtPwzAQhC0EEqXwA7hF4gIHw_oVF26oAoqE4AJny_UDUqVOaydB5dfjECROnHZWM7MrfQidErgkAPIqAQDnGIjEFGYMyz00IUJwPCMU9rOGrKmg7BAdpbQCYBK4mKD1s_sskouVS0XjC37OFhd421VBfzV1FZrgCpvdXrdV79JNkXah_XApp3Wwhet13WWrCUNZh7Zqu3UTf7xh66uo60KbQbX5xTE68LpO7uR3TtHb_d3rfIGfXh4e57dP2DBStthqS6VkzEvDrVmC0J5LazUxpSi9NdRIsJY548XSCMcI1Z5SLqE00vjrJZuis_HuJjbbzqVWrZouhvxS0QyKgRSE5hQZUyY2KUXn1SZWax13ioAaqKqRqspU1UBVydyhYyflbHh38e_y_6VvjqJ8hg</recordid><startdate>20180201</startdate><enddate>20180201</enddate><creator>Abbas, Samir Y.</creator><creator>El-Bayouki, Khairy A. M.</creator><creator>Basyouni, Wahid M.</creator><creator>Mostafa, Eslam A.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope></search><sort><creationdate>20180201</creationdate><title>New series of 4(3H)-quinazolinone derivatives: syntheses and evaluation of antitumor and antiviral activities</title><author>Abbas, Samir Y. ; El-Bayouki, Khairy A. M. ; Basyouni, Wahid M. ; Mostafa, Eslam A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-dad27733f7c4dcb05af47dda1c656fdc2c70dd3ecf5bc5e312af224706c7cf9b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adenocarcinoma</topic><topic>Anticancer properties</topic><topic>Antitumor activity</topic><topic>Antiviral activity</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Breast cancer</topic><topic>Cancer</topic><topic>Cell Biology</topic><topic>Cytotoxicity</topic><topic>Derivatives</topic><topic>Doxorubicin</topic><topic>Epithelial cells</topic><topic>Hepatocytes</topic><topic>Liver</topic><topic>Liver cancer</topic><topic>Original Research</topic><topic>Pharmacology/Toxicology</topic><topic>Pyrazoles</topic><topic>Quinazolinone</topic><topic>Synthesis</topic><topic>Toxicity</topic><topic>Tumor cell lines</topic><topic>Zanamivir</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abbas, Samir Y.</creatorcontrib><creatorcontrib>El-Bayouki, Khairy A. M.</creatorcontrib><creatorcontrib>Basyouni, Wahid M.</creatorcontrib><creatorcontrib>Mostafa, Eslam A.</creatorcontrib><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Medicinal chemistry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abbas, Samir Y.</au><au>El-Bayouki, Khairy A. M.</au><au>Basyouni, Wahid M.</au><au>Mostafa, Eslam A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New series of 4(3H)-quinazolinone derivatives: syntheses and evaluation of antitumor and antiviral activities</atitle><jtitle>Medicinal chemistry research</jtitle><stitle>Med Chem Res</stitle><date>2018-02-01</date><risdate>2018</risdate><volume>27</volume><issue>2</issue><spage>571</spage><epage>582</epage><pages>571-582</pages><issn>1054-2523</issn><eissn>1554-8120</eissn><abstract>New series of 3-(3-trifluoromethylphenyl)-6-iodo-4(3
H
)-quinazolinone derivatives bearing thiosemicarbazones, pyrazoles, azomethine moieties at C-2 were synthesized. The obtained products were screened for their expected anticancer activity against; human liver cancer cell line (HepG2), breast cancer cell line (MCF-7) and human lung adenocarcinoma epithelial cell line (A549) tumor cell lines. Cytotoxicity of the synthesized compounds showed good IC
50
for some products in comparison with the standard drug, doxorubicin. On the other hand, antiviral activity of the synthesized products against H
5
N
1
showed moderate to weak activity compared to Zanamivir reference drug.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s00044-017-2083-7</doi><tpages>12</tpages></addata></record> |
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| subjects | Adenocarcinoma Anticancer properties Antitumor activity Antiviral activity Biochemistry Biomedical and Life Sciences Biomedicine Breast cancer Cancer Cell Biology Cytotoxicity Derivatives Doxorubicin Epithelial cells Hepatocytes Liver Liver cancer Original Research Pharmacology/Toxicology Pyrazoles Quinazolinone Synthesis Toxicity Tumor cell lines Zanamivir |
| title | New series of 4(3H)-quinazolinone derivatives: syntheses and evaluation of antitumor and antiviral activities |
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