New series of 4(3H)-quinazolinone derivatives: syntheses and evaluation of antitumor and antiviral activities

New series of 4(3H)-quinazolinone derivatives: syntheses and evaluation of antitumor and antiviral activities

New series of 3-(3-trifluoromethylphenyl)-6-iodo-4(3 H )-quinazolinone derivatives bearing thiosemicarbazones, pyrazoles, azomethine moieties at C-2 were synthesized. The obtained products were screened for their expected anticancer activity against; human liver cancer cell line (HepG2), breast canc...

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Veröffentlicht in:Medicinal chemistry research 2018-02, Vol.27 (2), p.571-582
Hauptverfasser: Abbas, Samir Y., El-Bayouki, Khairy A. M., Basyouni, Wahid M., Mostafa, Eslam A.
Format: Artikel
Sprache:eng
Schlagworte:
Adenocarcinoma
Anticancer properties
Antitumor activity
Antiviral activity
Biochemistry
Biomedical and Life Sciences
Biomedicine
Breast cancer
Cancer
Cell Biology
Cytotoxicity
Derivatives
Doxorubicin
Epithelial cells
Hepatocytes
Liver
Liver cancer
Original Research
Pharmacology/Toxicology
Pyrazoles
Quinazolinone
Synthesis
Toxicity
Tumor cell lines
Zanamivir
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Zusammenfassung:New series of 3-(3-trifluoromethylphenyl)-6-iodo-4(3 H )-quinazolinone derivatives bearing thiosemicarbazones, pyrazoles, azomethine moieties at C-2 were synthesized. The obtained products were screened for their expected anticancer activity against; human liver cancer cell line (HepG2), breast cancer cell line (MCF-7) and human lung adenocarcinoma epithelial cell line (A549) tumor cell lines. Cytotoxicity of the synthesized compounds showed good IC 50 for some products in comparison with the standard drug, doxorubicin. On the other hand, antiviral activity of the synthesized products against H 5 N 1 showed moderate to weak activity compared to Zanamivir reference drug.
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-017-2083-7