DRUG INDUCED ACUTE KIDNEY INJURY: AN EXPERIMENTAL ANIMAL STUDY

First sample determined baseline values whereas 2nd sample was taken just before sacrificing the animal. [...]normal biological values and intact renal architecture noted in group B. Post dose blood samples of Group C revealed acute rise in blood urea and serum creatinine levels in excess of 200%. In group E, coadministration of amphotericin B and cyclosporine resulted in marked nephrotoxicity as evident from acute rise in blood urea, serum creatinine, hyponatremia and hyperkalemia, and marked, grade-3 necrosis of renal tubules (fig-1 & 2). In a study conducted in 2001, it was discovered that patients who received parenteral amphotericin B therapy and developed acute renal failure had substantially higher mortality, longer hospital stay, and higher cost of treatment than those who did not have acute renal failure20.