Survey Reactivity of Some Substituted Quinazolinones with Pentafluoro(chloro)pyridine

A new series of 4‐hetroaryl substituted quinazolines were designed and synthesized by the reaction of pentafluoro(chloro)pyridine and 2‐substituted quinazolinone. The aromatic nucleophilic substitution of pentafluoro(chloro)pyridine with quinazolinone occurs at the 4‐position of pyridine ring by the...

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Veröffentlicht in:Journal of heterocyclic chemistry 2018-02, Vol.55 (2), p.475-480
Hauptverfasser: Ranjbar‐Karimi, Reza, Davodian, Tayebeh, Mehrabi, Hossein
Format: Artikel
Sprache:eng
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Zusammenfassung:A new series of 4‐hetroaryl substituted quinazolines were designed and synthesized by the reaction of pentafluoro(chloro)pyridine and 2‐substituted quinazolinone. The aromatic nucleophilic substitution of pentafluoro(chloro)pyridine with quinazolinone occurs at the 4‐position of pyridine ring by the oxygen site (O‐centered nucleophile) of quinazolinone. The structures of all the compounds were confirmed by IR, 1H NMR, 19F NMR, and 13C NMR spectroscopy as well as elemental analysis.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.3067