Relationship between baseline systolic blood pressure and long-term outcomes in acute heart failure patients treated with TRV027: an exploratory subgroup analysis of BLAST-AHF

Relationship between baseline systolic blood pressure and long-term outcomes in acute heart failure patients treated with TRV027: an exploratory subgroup analysis of BLAST-AHF

Introduction TRV027, a ‘biased’ ligand of the angiotensin II type 1 receptor (AT1R), did not affect a composite clinical outcome at 30 days in a phase 2b acute heart failure (AHF) trial (BLAST-AHF). Methods Post-hoc analyses from BLAST-AHF ( n  = 618) examined the effects of TRV027 by baseline systo...

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Veröffentlicht in:Clinical research in cardiology 2018-02, Vol.107 (2), p.170-181
Hauptverfasser: Cotter, Gad, Davison, Beth A., Butler, Javed, Collins, Sean P., Ezekowitz, Justin A., Felker, G. Michael, Filippatos, Gerasimos, Levy, Phillip D., Metra, Marco, Ponikowski, Piotr, Teerlink, John R., Voors, Adriaan A., Senger, Stefanie, Bharucha, David, Goin, Kathleen, Soergel, David G., Pang, Peter S.
Format: Artikel
Sprache:eng
Schlagworte:
Angiotensin
Angiotensin II
Beta blockers
Blood pressure
Cardiology
Cardiovascular diseases
Creatinine
Health risk assessment
Heart
Heart diseases
Heart failure
Medicine
Medicine & Public Health
Mortality
Original Paper
Patients
Renal function
Subgroups
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Zusammenfassung:Introduction TRV027, a ‘biased’ ligand of the angiotensin II type 1 receptor (AT1R), did not affect a composite clinical outcome at 30 days in a phase 2b acute heart failure (AHF) trial (BLAST-AHF). Methods Post-hoc analyses from BLAST-AHF ( n  = 618) examined the effects of TRV027 by baseline systolic blood pressure (SBP) on changes in renal function and 180-day outcomes. Interactions between baseline SBP and select endpoints were identified utilizing a subpopulation treatment effect pattern plots (STEPP) analysis, then grouping of patients by SBP tertile: < 127, ≥ 127 to
ISSN:1861-0684
1861-0692
DOI:10.1007/s00392-017-1168-0