Induction and repair of DNA double-strand breaks in rat cerebellar cortex exposed to 60Co γ-rays

Induction and repair of DNA double-strand breaks in rat cerebellar cortex exposed to 60Co γ-rays

The induction and repair of DNA double-strand breaks are studied using the immunohistochemical staining procedure of paraffin-embedded rat cerebellum tissues after exposure to γ-rays of 60 Co. The dose dependence of radiation-induced colocalized γH2AX/53BP1 foci is studied and its linear character i...

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Veröffentlicht in:Physics of particles and nuclei letters 2018, Vol.15 (1), p.121-126
Hauptverfasser: Bulanova, T. S., Zadneprianetc, M. G., Ježková, L., Kruglyakova, E. A., Smirnova, E. V., Boreyko, A. V.
Format: Artikel
Sprache:eng
Schlagworte:
Cerebellum
Deoxyribonucleic acid
DNA
DNA damage
Ecology and Nuclear Medicine
Eukaryotes
Particle and Nuclear Physics
Physics
Physics and Astronomy
Radiation dosage
Radiation effects
Radiobiology
Repair
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Zusammenfassung:The induction and repair of DNA double-strand breaks are studied using the immunohistochemical staining procedure of paraffin-embedded rat cerebellum tissues after exposure to γ-rays of 60 Co. The dose dependence of radiation-induced colocalized γH2AX/53BP1 foci is studied and its linear character is established. It is shown that these foci are efficiently eliminated 24 h after irradiation.
ISSN:1547-4771
1531-8567
DOI:10.1134/S1547477118010041