Brief Report: Frequency of Monitoring Kidney Function in HIV-Uninfected Persons Using Daily Oral Tenofovir Disoproxil Fumarate Pre-exposure Prophylaxis

Brief Report: Frequency of Monitoring Kidney Function in HIV-Uninfected Persons Using Daily Oral Tenofovir Disoproxil Fumarate Pre-exposure Prophylaxis

BACKGROUND:Wide-scale implementation of oral tenofovir-based pre-exposure prophylaxis (PrEP) for HIV prevention is now policy in many settings. However, the optimal frequency for monitoring kidney function remains uncertain. We investigated the impact of 6-monthly compared with 3-monthly creatinine...

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Veröffentlicht in:Journal of acquired immune deficiency syndromes (1999) 2018-02, Vol.77 (2), p.206-211
Hauptverfasser: Mugwanya, Kenneth K, Baeten, Jared M, Wyatt, Christina, Mugo, Nelly R, Celum, Connie L, Ronald, Allan, Kiarie, John, Katabira, Elly, Heffron, Renee
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Aged, 80 and over
Anti-HIV Agents - administration & dosage
Anti-HIV Agents - adverse effects
Antiretroviral drugs
Blood pressure
Creatinine
Creatinine - blood
Delivery scheduling
Disease prevention
Expenditures
Exposure
Female
HIV
Human immunodeficiency virus
Humans
Hypertension
Kenya
Kidney diseases
Kidney Function Tests
Male
Medical screening
Metabolic Clearance Rate
Middle Aged
Monitoring
Pre-Exposure Prophylaxis - methods
Prophylaxis
Renal function
Renal Insufficiency - chemically induced
Renal Insufficiency - diagnosis
Tenofovir
Tenofovir - administration & dosage
Tenofovir - adverse effects
Uganda
Young Adult
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Zusammenfassung:BACKGROUND:Wide-scale implementation of oral tenofovir-based pre-exposure prophylaxis (PrEP) for HIV prevention is now policy in many settings. However, the optimal frequency for monitoring kidney function remains uncertain. We investigated the impact of 6-monthly compared with 3-monthly creatinine clearance (CrCl) monitoring on the identification of moderate kidney dysfunction, defined as CrCl
ISSN:1525-4135
1944-7884
DOI:10.1097/QAI.0000000000001575