Latent dysbetalipoproteinaemia precipitated by HIV-protease inhibitors

Latent dysbetalipoproteinaemia precipitated by HIV-protease inhibitors

A man with advanced HIV-1-infection had florid-yellow-orange papules on the backs of his hands. The patient may have had impaired lipoprotein-receptor-related protein (LRP)-mediated endocytosis of very low-dose lipoprotein (VLDL) which was compromised further than it needed to be by HIV-protease inh...

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Veröffentlicht in:The Lancet (British edition) 1999-05, Vol.353 (9165), p.1678-1678
Hauptverfasser: Lister, RK, Youle, M, Nair, DR, Winder, AF, Rustin, MHA
Format: Artikel
Sprache:eng
Schlagworte:
Apolipoprotein E2
Apolipoproteins E - genetics
Drug therapy
HIV
HIV Infections - drug therapy
HIV-1
Homozygote
Human immunodeficiency virus
Humans
Hyperlipoproteinemia Type III - chemically induced
Lipids
Male
Medical research
Protease Inhibitors - adverse effects
Protease Inhibitors - therapeutic use
Proteinase inhibitors
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Beschreibung
Zusammenfassung:A man with advanced HIV-1-infection had florid-yellow-orange papules on the backs of his hands. The patient may have had impaired lipoprotein-receptor-related protein (LRP)-mediated endocytosis of very low-dose lipoprotein (VLDL) which was compromised further than it needed to be by HIV-protease inhibitors.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(99)01449-X