Intensive insulin therapy for patients in paediatric intensive care: a prospective, randomised controlled study

Summary Background Critically ill infants and children often develop hyperglycaemia, which is associated with adverse outcome; however, whether lowering blood glucose concentrations to age-adjusted normal fasting values improves outcome is unknown. We investigated the effect of targeting age-adjuste...

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Veröffentlicht in:	The Lancet (British edition) 2009-02, Vol.373 (9663), p.547-556
Hauptverfasser:	Vlasselaers, Dirk, MD, Milants, Ilse, RN, Desmet, Lars, MD, Wouters, Pieter J, MSc, Vanhorebeek, Ilse, PhD, van den Heuvel, Ingeborg, MD, Mesotten, Dieter, MD, Casaer, Michael P, MD, Meyfroidt, Geert, MD, Ingels, Catherine, MD, Muller, Jan, MD, Van Cromphaut, Sophie, MD, Schetz, Miet, MD, Van den Berghe, Greet, Prof
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adults Belgium Blood Blood Glucose - drug effects Child Child, Preschool Clinical medicine College admissions Critical Care - methods Diabetes Female Glucose Heart surgery Hospital Mortality Hospitals Humans Hypoglycemia - chemically induced Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - adverse effects Hypoglycemic Agents - therapeutic use Infant Infant, Newborn Infants Insulin Insulin - administration & dosage Insulin - adverse effects Insulin - therapeutic use Intensive care Intensive Care Units, Pediatric Internal Medicine Length of Stay Male Medical disorders Mortality Prospective Studies Risk factors Survival
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Zusammenfassung:	Summary Background Critically ill infants and children often develop hyperglycaemia, which is associated with adverse outcome; however, whether lowering blood glucose concentrations to age-adjusted normal fasting values improves outcome is unknown. We investigated the effect of targeting age-adjusted normoglycaemia with insulin infusion in critically ill infants and children on outcome. Methods In a prospective, randomised controlled study, we enrolled 700 critically ill patients, 317 infants (aged
ISSN:	0140-6736 1474-547X
DOI:	10.1016/S0140-6736(09)60044-1