(alpha)-Ketoglutarate and Postoperative Muscle Catabolism

(alpha)-Ketoglutarate and Postoperative Muscle Catabolism

The hypothesis that muscle protein catabolism after trauma is associated with a shortage of alpha-ketoglutarate, rather than glutamine, was tested. Addition of alpha-ketoglutarate to postoperative total parenteral nutrition prevented the decrease in muscle protein synthesis and free glutamine that u...

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Veröffentlicht in:The Lancet (British edition) 1990-03, Vol.335 (8691), p.701
Hauptverfasser: Wernerman, Jan, Hammarqvist, Folke, Vinnars, Erik
Format: Artikel
Sprache:eng
Schlagworte:
Health care
Muscular system
Parenteral nutrition
Protein synthesis
Proteins
Surgery
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Zusammenfassung:The hypothesis that muscle protein catabolism after trauma is associated with a shortage of alpha-ketoglutarate, rather than glutamine, was tested. Addition of alpha-ketoglutarate to postoperative total parenteral nutrition prevented the decrease in muscle protein synthesis and free glutamine that usually occurs after surgery. alpha-ketoglutarate supplementation may improve recovery after trauma.
ISSN:0140-6736
1474-547X