PLACEBO-CONTROLLED TRIAL OF INTRAVENOUS PENICILLIN FOR SEVERE AND LATE LEPTOSPIROSIS

PLACEBO-CONTROLLED TRIAL OF INTRAVENOUS PENICILLIN FOR SEVERE AND LATE LEPTOSPIROSIS

The effect of a 7-day course of intravenous penicillin (6 million units/day) on severe, advanced leptospirosis was examined in a randomised, placebo-controlled, double-blind trial involving 42 patients. Every measurable aspect of the disease was favourably affected by penicillin. Fever lasted more t...

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Veröffentlicht in:The Lancet (British edition) 1988-02, Vol.331 (8583), p.433-435
Hauptverfasser: Watt, George, Linda Tuazon, MA, Santiago, Edna, Padre, LaurenaP, Calubaquib, Carmen, Ranoa, CatherineP, Laughlin, LarryW
Format: Artikel
Sprache:eng
Schlagworte:
Medical research
Penicillin
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Zusammenfassung:The effect of a 7-day course of intravenous penicillin (6 million units/day) on severe, advanced leptospirosis was examined in a randomised, placebo-controlled, double-blind trial involving 42 patients. Every measurable aspect of the disease was favourably affected by penicillin. Fever lasted more than twice as long in the placebo group (11·6 [SD 8·34] days vs 4·7 [4·19] days, p
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(88)91230-5