Dual Therapy With Darunavir and Ritonavir Plus Lamivudine vs Triple Therapy With Darunavir and Ritonavir Plus Tenofovir Disoproxil Fumarate and Emtricitabine or Abacavir and Lamivudine for Maintenance of Human Immunodeficiency Virus Type 1 Viral Suppression: Randomized, Open-Label, Noninferiority DUAL-GESIDA 8014-RIS-EST45 Trial

Our objective was to assess the therapeutic noninferiority of dual therapy with darunavir/ritonavir and lamivudine compared to triple therapy with darunavir/ritonavir plus 2 nucleos(t)ides for maintenance of human immunodeficiency virus type 1 (HIV-1) suppression. This was a multicenter, open-label,...

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Veröffentlicht in:	Clinical infectious diseases 2017-12, Vol.65 (12), p.2112-2118
Hauptverfasser:	Pulido, Federico, Ribera, Esteban, Lagarde, María, Pérez-Valero, Ignacio, Palacios, Rosario, Iribarren, José A., Payeras, Antoni, Domingo, Pere, Sanz, José, Cervero, Miguel, Curran, Adrián, Rodríguez-Gómez, Francisco J., Téllez, María J., Ryan, Pablo, Barrufet, Pilar, Knobel, Hernando, Rivero, Antonio, Alejos, Belén, Yllescas, María, Arribas, José R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abacavir Adult Anti-HIV Agents - administration & dosage Anti-HIV Agents - therapeutic use Antiretroviral drugs Antiviral drugs ARTICLES AND COMMENTARIES CD4 Lymphocyte Count Cholesterol Clinical trials Confidence intervals Darunavir - administration & dosage Darunavir - therapeutic use Dideoxynucleosides - administration & dosage Dideoxynucleosides - therapeutic use Emtricitabine Emtricitabine - administration & dosage Emtricitabine - therapeutic use Female High density lipoprotein HIV HIV Infections - drug therapy HIV Infections - virology HIV Protease Inhibitors - administration & dosage HIV Protease Inhibitors - therapeutic use HIV-1 - drug effects Human immunodeficiency virus Humans Lamivudine Lamivudine - administration & dosage Lamivudine - therapeutic use Male Medication Therapy Management Middle Aged Motivation Randomization Ribonucleic acid Ritonavir Ritonavir - administration & dosage Ritonavir - therapeutic use RNA RNA, Viral - blood Tenofovir Tenofovir - administration & dosage Tenofovir - therapeutic use Therapy Viral Load - drug effects Viruses
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Zusammenfassung:	Our objective was to assess the therapeutic noninferiority of dual therapy with darunavir/ritonavir and lamivudine compared to triple therapy with darunavir/ritonavir plus 2 nucleos(t)ides for maintenance of human immunodeficiency virus type 1 (HIV-1) suppression. This was a multicenter, open-label, noninferiority trial (margin 12%). Patients with HIV-1 RNA
ISSN:	1058-4838 1537-6591
DOI:	10.1093/cid/cix734