Psychological effects of withdrawal of growth hormone therapy from adults with growth hormone deficiency

Summary objective Growth hormone (GH) is known to be required for physical well‐being. Although it is also widely believed to be important for quality of life (QoL) and psychological health, there is less supportive evidence. The objective of this study was to investigate the psychological effects of discontinuation of GH replacement from adults with severe GH deficiency (GHD). design A double‐blind, placebo‐controlled trial in which GH replacement therapy was discontinued for 3 months from 12 of 21 GH‐deficient adults, where nine continued with GH replacement. patients GH‐treated adults (10 men, 11 women), all with severe GHD (peak GH