HLA-DRB3 0101 is associated with Graves' disease in Jamaicans

HLA-DRB3 0101 is associated with Graves' disease in Jamaicans

OBJECTIVES Graves' disease is associated with different human leucocyte antigen (HLA) genes in different populations. This study was designed to examine the HLA class II associations with Graves' disease in Jamaicans. PATIENTS One hundred and six Jamaicans with Graves' disease and 104...

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Veröffentlicht in:Clinical endocrinology (Oxford) 2001-12, Vol.55 (6), p.805-808
Hauptverfasser: Smikle, Monica Fisher, Pascoe, Rosemarie Wright, Barton, Everard, Morgan, Owen, Christian, Nicole, Dowe, Gwendolyn, Roye-Green, Karen, Bailey, Valerie, James, Owen
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Endocrinopathies
Medical sciences
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Thyroid. Thyroid axis (diseases)
Tropical medicine
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Zusammenfassung:OBJECTIVES Graves' disease is associated with different human leucocyte antigen (HLA) genes in different populations. This study was designed to examine the HLA class II associations with Graves' disease in Jamaicans. PATIENTS One hundred and six Jamaicans with Graves' disease and 104 controls. DESIGN Oligotyping for HLA‐DRB1, DRB3, DQA1 and DQB1 alleles was performed using the polymerase chain reaction sequence specific oligonucleotide probe (PCR‐SSOP) technique. RESULTS The frequency of HLA‐DRB3 *0101 was increased significantly in the patients compared to controls (38·7% vs. 19·2%; RR = 2·72; Pc 
ISSN:0300-0664
1365-2265
DOI:10.1046/j.1365-2265.2001.01414.x