FGFR3 dysregulation in multiple myeloma: frequency and prognostic relevance

The t(4:14) translocation affects two potential oncogenes, FGFR3 and MMSET, in multiple myeloma (MM). We investigated the frequency of FGFR3 dysregulation and its prognostic value in MM. FGFR3 mRNA levels were determined in 110 diagnostic bone marrow (BM) samples from MM patients. In addition, selec...

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Veröffentlicht in:	British journal of haematology 2002-06, Vol.117 (3), p.626-628
Hauptverfasser:	Rasmussen, Thomas, Hudlebusch, Heidi Rye, Knudsen, Lene Meldgaard, Johnsen, Hans Erik
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biomarkers, Tumor - genetics Carrier Proteins Female FGFR3 Fibroblast Growth Factors - genetics Follow-Up Studies Gene Expression Regulation, Neoplastic Hematology High Mobility Group Proteins - genetics Histone-Lysine N-Methyltransferase Humans Immunodeficiencies. Immunoglobulinopathies Immunoglobulinopathies Immunopathology Male Medical sciences MMSET multiple myeloma Multiple Myeloma - genetics Neoplasm Proteins - genetics Prognosis prognostic factor Protein-Tyrosine Kinases real‐time RT–PCR Receptor, Fibroblast Growth Factor, Type 3 Receptors, Fibroblast Growth Factor - genetics Repressor Proteins RNA, Messenger - genetics RNA, Neoplasm - genetics Survival Rate
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Zusammenfassung:	The t(4:14) translocation affects two potential oncogenes, FGFR3 and MMSET, in multiple myeloma (MM). We investigated the frequency of FGFR3 dysregulation and its prognostic value in MM. FGFR3 mRNA levels were determined in 110 diagnostic bone marrow (BM) samples from MM patients. In addition, selected BM samples were screened for elevated MMSET mRNA levels. 14·5% (16/110) of MM BM samples showed dysregulated FGFR3 expression. Follow‐up of 76 MM patients showed no significant difference between FGFR3 dysfunction and survival (P = 0·3) or correlation with known prognostic factors. Further, no linear relation was observed between FGFR3 and MMSET levels.
ISSN:	0007-1048 1365-2141
DOI:	10.1046/j.1365-2141.2002.03429.x