In Vivo studies of Ophthalmic Ocular Insert Containing Aciclovir

The draw backs of other ophthalmic formulations (solutions, suspensions, ointment) like poor bioavailability, patient non compliance, quick drug elimination was overcome by formulating the drug in ocusert formulation.1,2 The ocuserts was prepared by solvent casting technique using hydrophilic and hydrophobic polymers. Aciclovir drug is having half life of 2-4 hrs which is necessary for controlled release formulation.1The factors to be considered while formulating controlled drug release was shown in table no 1 Criteria for controlled release ocular insert are comfort, convenient to use, sterility, stability, easy to formulate, excipients used non irritant to the eyes MATERIALS AND METHODS: The institutional animal ethical committee (IAEC) approval was obtained before performing invivo drug release with the reference No: XIX/VELS/P.COL/12/2000/ CPCSEA/IAEC/O3.10.2016 .Eye irritation test was done to detect the damage of cornea, iris and conjuctivia caused by the formulation in the eye. In vivo Study: Eye Irritation Test5: The selected formulation F2 which shows promising in vitro drug release was subjected to eye irritation test after sterilized by UV radiation.