Hepatocyte Toll-like receptor 4 regulates alcoholic fatty liver disease in mice

Hepatocyte Toll-like receptor 4 regulates alcoholic fatty liver disease in mice

Increasing evidence suggests that gut-derived endotoxin/lipopolysaccharide (LPS) and its recognition by the cell surface receptor, Toll-like receptor 4 (TLR4), play important roles in alcohol-induced liver injury. [...]TLR4 is widely expressed in various cell types. [...]it still remains unclear whi...

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Veröffentlicht in:Alcohol (Fayetteville, N.Y.) N.Y.), 2018-02, Vol.66, p.90-90
Hauptverfasser: Jia, L., Chang, X., Liu, C., Lord, C.C., Ahmed, N., Lee, C.E., Lee, S., Mitchell, M.C., Scherer, P.E., Elmquist, J.K.
Format: Artikel
Sprache:eng
Schlagworte:
Alcohol use
Alcoholism
Fatty liver
Lipopolysaccharides
Liver
Liver diseases
TLR4 protein
Toll-like receptors
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Beschreibung
Zusammenfassung:Increasing evidence suggests that gut-derived endotoxin/lipopolysaccharide (LPS) and its recognition by the cell surface receptor, Toll-like receptor 4 (TLR4), play important roles in alcohol-induced liver injury. [...]TLR4 is widely expressed in various cell types. [...]it still remains unclear which TLR4-expressing cells contribute to the development of alcoholic liver disease (ALD).
ISSN:0741-8329
1873-6823
DOI:10.1016/j.alcohol.2017.11.014