THE GLYCINE REUPTAKE INHIBITOR ORG 25935 DECREASES ETHANOL INTAKE AND PREFERENCE IN MALE WISTAR RATS

Previous findings from our group indicate that accumbal glycine receptors (GlyRs) are involved in mediating the dopamine (DA) activating effects of ethanol (EtOH), and that administration of glycine locally into the nucleus accumbens (nAc) reduces EtOH consumption in EtOH high-preferring rats. Aims:...

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Veröffentlicht in:	Alcohol and alcoholism (Oxford) 2007-01, Vol.42 (1), p.11-18
Hauptverfasser:	MOLANDER, ANNA, LIDÖ, HELGA HÖIFÖDT, LÖF, ELIN, ERICSON, MIA, SÖDERPALM, BO
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Drinking - physiopathology Alcoholism - physiopathology Alcoholism and acute alcohol poisoning Animals Biological and medical sciences Choice Behavior - drug effects Dopamine - metabolism Dose-Response Relationship, Drug Glycine Agents - pharmacology Glycine Plasma Membrane Transport Proteins - antagonists & inhibitors Glycine Plasma Membrane Transport Proteins - physiology Male Medical sciences Nucleus Accumbens - drug effects Nucleus Accumbens - physiopathology Rats Rats, Wistar Receptors, Glycine - drug effects Receptors, Glycine - physiology Tetrahydronaphthalenes - antagonists & inhibitors Tetrahydronaphthalenes - pharmacology Toxicology
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Zusammenfassung:	Previous findings from our group indicate that accumbal glycine receptors (GlyRs) are involved in mediating the dopamine (DA) activating effects of ethanol (EtOH), and that administration of glycine locally into the nucleus accumbens (nAc) reduces EtOH consumption in EtOH high-preferring rats. Aims: The present study examines the influence of a systemically administered glycine reuptake inhibitor, Org 25935, on EtOH preference and intake, in male Wistar rats with an EtOH preference >60% (during continuous access to a bottle of EtOH, 6% v/v, and a bottle of water), called EP>60 rats, as well as in animals with an EtOH preference
ISSN:	0735-0414 1464-3502
DOI:	10.1093/alcalc/agl085