TESTOSTERONE INHIBITS THE ALPHA1C SUBUNIT OF L-TYPE CA2+ CHANNELS (CAV1.2) AND ALPHA1H T-TYPE CA2+ CHANNELS (CAV3.2) STABLY EXPRESSED IN HEK 293 CELLS

TESTOSTERONE INHIBITS THE ALPHA1C SUBUNIT OF L-TYPE CA2+ CHANNELS (CAV1.2) AND ALPHA1H T-TYPE CA2+ CHANNELS (CAV3.2) STABLY EXPRESSED IN HEK 293 CELLS

Testosterone reduces myocardial ischaemia in men with coronary artery disease (CAD), improves symptoms and exercise capacity in men with congestive heart failure (CHF), effects proposed to be due to testosterone-induced coronary, systemic and pulmonary vasodilatation. Here, Scragg et al present an a...

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Veröffentlicht in:The aging male 2004-03, Vol.7 (1), p.102
Hauptverfasser: Scragg, J L, Jones, R D, Jones, T H, Channer, K S, Peers, C
Format: Artikel
Sprache:eng
Schlagworte:
Androgens
Coronary vessels
Heart failure
Medical research
Men
Therapy
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Zusammenfassung:Testosterone reduces myocardial ischaemia in men with coronary artery disease (CAD), improves symptoms and exercise capacity in men with congestive heart failure (CHF), effects proposed to be due to testosterone-induced coronary, systemic and pulmonary vasodilatation. Here, Scragg et al present an abstract of their study on the effect of testosterone upon whole-cell Ca2+ channel currents in HEK 293 cells stably expressing either the main poreforming alpha1C subunit of a human L-type Ca2+ channel, or the alpha1H T-type Ca2+ channel.
ISSN:1368-5538
1473-0790