Formulation and Evaluation of Mouth Dissolving Tablets of Clozapine by Direct Compression Method

Clozapine was obtained from Sun pharma, Avicel(MCC) from Signet chemical, Ac-di-sol (Crosscarmellose) from FMC biopolymer, Cellosol (Crosscarmellose) from Microwax Ltd, Indore, PolyplasdoneXL (Crosspovidone) from Sun pharma, Explotab (SSG) from Forum bioscience, Camphor from Fine Chem Ltd., India, all other excipients used were of analytical grade. [...]magnesium stearate and Talc were added and subjected to compression. Water absorption ratio, R, was determined using equation: (ProQuest: ... denotes formula omitted.) Where, Wb = weight of the tablet before water absorption Wa = weight of the tablet after water absorption Three tablets from each formulation were analyzed performed and standard deviation was also determined. Scanning Electron Microscopy: This is done to examine the surface topography, texture of the formulations, morphology of fractured or sectioned surfaces, this provide important information about the porosity of the device in the matrix of the formulations by subjecting the formulations to SEM in dry state at the magnification X150 using a JEOL JSM-T330A Scanning Microscope as shown in Fig:13-18.