Inside Back Cover: A Bottom‐Up Proteomic Approach to Identify Substrate Specificity of Outer‐Membrane Protease OmpT (Angew. Chem. Int. Ed. 52/2017)

Peptide arrays are used to identify highly active substrates for the OmpT protease, as described by M. Mrksich, B. Liedberg, et al. in their Communication on page 16531 ff. By preparing the peptide arrays on self‐assembled monolayers, mass spectrometry (the SAMDI method) was used to characterize the extent of cleavage of each peptide. A commonly used mutant form of the protease, although regarded as having identical activity, instead had an altered specificity for its substrates.