Modulation of Uncoupling Protein 1 and Peroxisome Proliferator-Activated Receptor [gamma] Expression in Adipose Tissue in Obese Insulin-Resistant Dogs1

The role of peroxisome proliferator-activated receptors y (PPRAs) in adipogenesis, its effect on uncoupling protein 1 (UCP1) expression, and the involvement of UCP1 in energetic status led Leray et al to study their expression in visceral adipose tissue in obese dogs. Results of their study indicate a parallel decrease in adipose tissue UCP1 and PPARy mRNA expression in the dogs when obese and insulin resistant. PPARy expression in obese animals, where adipogenesis is greatly reduced, seems to have little relevance.