The addition of β-ketoacids to 4-(trifluoromethyl)pyrimidin- 2(1Н)-ones with decarboxylation: an effective method for the synthesis of 4-(2-oxoalkyl)-6-(trifluoromethyl)-3,4-dihydropyrimidin-2-ones

The addition of β-ketoacids to 4-(trifluoromethyl)pyrimidin- 2(1Н)-ones with decarboxylation: an effective method for the synthesis of 4-(2-oxoalkyl)-6-(trifluoromethyl)-3,4-dihydropyrimidin-2-ones

β-Ketoacids reacted with 4-(trifluoromethyl)pyrimidin-2(1 Н )-ones according to the mechanism of Michael addition–decarboxylation, forming 4-(2-oxoalkyl)-6-(trifluoromethyl)-3,4-dihydropyrimidin-2-ones.

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Veröffentlicht in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2017-10, Vol.53 (10), p.1124-1127
Hauptverfasser: Tkachuk, Viktor M., Mel’nikov, Serhiy V., Sukach, Volodymyr A., Vovk, Mykhailo V.
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry and Materials Science
Decarboxylation
Organic Chemistry
Pharmacy
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Zusammenfassung:β-Ketoacids reacted with 4-(trifluoromethyl)pyrimidin-2(1 Н )-ones according to the mechanism of Michael addition–decarboxylation, forming 4-(2-oxoalkyl)-6-(trifluoromethyl)-3,4-dihydropyrimidin-2-ones.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-017-2182-x