In vitro Antibacterial Evaluation of 1,2,4-Triazole Compounds Containing Purine Moiety
9H-[1,2,4]Triazolo[4,3-g]purin-5-amine ( 2 ) was synthesized by reaction of 6-hydrazinyl-7H-purin-2-amine ( 1a ) with formic acid under reflux conditions. Treating compound 1a in ethanol with CS 2 in the presence of KOH yielded 5-amino-3H-[1,2,4]triazolo[4,3-g]purine-3-thione ( 3 ). The new synthesi...
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| Veröffentlicht in: | Chemistry of natural compounds 2017-11, Vol.53 (6), p.1137-1139 |
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| Format: | Artikel |
| Sprache: | eng |
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| Online-Zugang: | Volltext |
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| Zusammenfassung: | 9H-[1,2,4]Triazolo[4,3-g]purin-5-amine (
2
) was synthesized by reaction of 6-hydrazinyl-7H-purin-2-amine (
1a
) with formic acid under reflux conditions. Treating compound
1a
in ethanol with CS
2
in the presence of KOH yielded 5-amino-3H-[1,2,4]triazolo[4,3-g]purine-3-thione (
3
). The new synthesized compounds were characterized using IR,
1
H NMR, and elemental analysis. The synthesized compounds have been screened for antibacterial activity. |
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| ISSN: | 0009-3130 1573-8388 |
| DOI: | 10.1007/s10600-017-2217-7 |