In memoriam: Henri Sarles, MD, PhD Professor of Medicine, Pioneer in pancreatic research 1922–2017

[...]the first lesions of chronic pancreatitis are protein precipitates, which later calcify and result in damage of the pancreatic ducts.Acute pancreatitis is the first clinical sign of already developed chronic pancreatitis.[...]acute pancreatitis is not the cause of chronic pancreatitis.Pathological observations (the necrosis-fibrosis theory by Klöppel and Maillet, 1991, 1992), clinical long-term data (Ammann et al., 1996) and genetic findings in hereditary pancreatitis (Whitcomb et al., 1996) have provided evidence for many other mechanisms.