All naturally occurring autoantibodies against the NMDA receptor subunit NR1 have pathogenic potential irrespective of epitope and immunoglobulin class

Autoantibodies of the IgG class against N -methyl- d -aspartate-receptor subunit NR1 (NMDAR1) were first described in anti-NMDAR encephalitis and seen as disease indicators. Recent work on together over 5000 individuals challenged this exclusive view by showing age-dependently up to >20% NMDAR1-a...

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Veröffentlicht in:Molecular psychiatry 2017-12, Vol.22 (12), p.1776-1784
Hauptverfasser: Castillo-Gómez, E, Oliveira, B, Tapken, D, Bertrand, S, Klein-Schmidt, C, Pan, H, Zafeiriou, P, Steiner, J, Jurek, B, Trippe, R, Prüss, H, Zimmermann, W-H, Bertrand, D, Ehrenreich, H, Hollmann, M
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Sprache:eng
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