The depletion of MARVELD1 leads to murine placenta accreta via integrin [beta]4-dependent trophoblast cell invasion

The depletion of MARVELD1 leads to murine placenta accreta via integrin [beta]4-dependent trophoblast cell invasion

The placenta is a remarkable organ, it serves as the interface between the mother and the fetus. Proper invasion of trophoblast cells is required for a successful pregnancy. Previous studies have found that the adhesion molecule integrin [beta]4 plays important roles during trophoblast cell invasion...

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Veröffentlicht in:Journal of cellular physiology 2018-03, Vol.233 (3), p.2257
Hauptverfasser: Chen, Yue, Zhang, Hui, Han, Fang, Yue, Lei, Qiao, Chunxiao, Zhang, Yao, Dou, Peng, Liu, Weizhe, Li, Yu
Format: Artikel
Sprache:eng
Schlagworte:
Birth rate
Fetuses
Mice
Placenta
Pregnancy
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Zusammenfassung:The placenta is a remarkable organ, it serves as the interface between the mother and the fetus. Proper invasion of trophoblast cells is required for a successful pregnancy. Previous studies have found that the adhesion molecule integrin [beta]4 plays important roles during trophoblast cell invasion. Here, we found that the overall birth rate of the MARVELD1 knockout mouse is much lower than that of the wild-type mouse (p
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.26098