Novel structures of Zn(II) biometal cation with the biologically active substituted acetic acid and nitrogen donor ligands: Synthesis, spectral, phosphate diester catalytic hydrolysis and anti‐microbial studies

The complexes [Zn(methoxyacetate)21,10‐phenanthroline] 1 and [Zn2(phenylacetate)4(quinoline)2] 2, were prepared and characterized by IR‐spectroscopy, UV–Visible spectroscopy, 1H and 13C NMR spectroscopy, single crystal X‐ray diffraction. BNPP hydrolysis of the complexes and their parent nitrogen ligands were scanned, the results indicated that the hydrolysis rates of BNPP were 4.5 × 104 and 6.2 × 105 for (1) and (2), respectively. In addition, anti‐bacterial activities were scanned to investigate the effect of complexation on their activity against Gram‐positive (S. epidermidis, S. aureus, E. faecalis, M. luteus and B. Subtilis) and Gram‐negative (K. pneumonia, E. coli, P. Mirabilis and P. Aeruginosa) bacteria using agar well‐diffusion method. Complex 1 showed high activity against G−and G+ bacteria except against E. faecalis and P. Aeruginosa. Complex 2 did not show any activity against G− or G+ bacteria. This work reports the synthesis and characterization of new mixed ligand Zn(II) complexes based on the biologically active substituted acetic acid and nitrogen donor ligands. The crystal structures of complexes 1 and 2 were determined using single‐crystal X‐ray diffraction. In‐vitro anti‐bacterial activity of the prepared complexes and their parent ligands were investigated against different Gram‐positive and Gram‐negative bacteria using agar diffusion method. BNPP hydrolysis of the complexes and their parent nitrogen ligands were determined.