Potassium Hydroxide‐Catalyzed Alkynylation of Heteroaromatic N‐Oxides with Terminal Alkynes

Potassium Hydroxide‐Catalyzed Alkynylation of Heteroaromatic N‐Oxides with Terminal Alkynes

An efficient potassium hydroxide‐catalyzed alkynylation of heteroaromatic N‐oxides under transition‐metal‐free conditions with the assistance of visible‐light has been developed. Various C2‐alkynylheterocycles were obtained in up to 92% yield with good functional group tolerance. This new method is...

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Veröffentlicht in:Advanced synthesis & catalysis 2017-11, Vol.359 (22), p.3922-3926
Hauptverfasser: Chen, Xiaopei, Yang, Fangfang, Cui, Xiuling, Wu, Yangjie
Format: Artikel
Sprache:eng
Schlagworte:
Alkynes
alkynylation
Functional groups
Potash
Potassium
potassium hydroxide-catalyzed
Potassium hydroxides
quinoline N-oxides
transition-metal-free
visible-light
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Zusammenfassung:An efficient potassium hydroxide‐catalyzed alkynylation of heteroaromatic N‐oxides under transition‐metal‐free conditions with the assistance of visible‐light has been developed. Various C2‐alkynylheterocycles were obtained in up to 92% yield with good functional group tolerance. This new method is operational simple, highly efficient, atom economic, and environmental friendly.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201700931