Cover Feature: Encapsulating pH‐Responsive Doxorubicin–Phthalocyanine Conjugates in Mesoporous Silica Nanoparticles for Combined Photodynamic Therapy and Controlled Chemotherapy (Chem. Eur. J. 65/2017)
Zinc(II) phthalocyanine (ZnPc) was conjugated with doxorubicin (Dox) through an acid‐cleavable hydrazone linker, and the resulting conjugate was encapsulated into mesoporous silica nanoparticles. Upon internalization into cancer cells, Dox was released after acidic cleavage of the hydrazone linker....
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| Veröffentlicht in: | Chemistry : a European journal 2017-11, Vol.23 (65), p.16411-16411 |
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| container_issue | 65 |
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| container_title | Chemistry : a European journal |
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| creator | Wong, Roy C. H Ng, Dennis K. P Fong, Wing‐Ping Lo, Pui‐Chi |
| description | Zinc(II) phthalocyanine (ZnPc) was conjugated with doxorubicin (Dox) through an acid‐cleavable hydrazone linker, and the resulting conjugate was encapsulated into mesoporous silica nanoparticles. Upon internalization into cancer cells, Dox was released after acidic cleavage of the hydrazone linker. The synergistic effect of the chemocytotoxic agent and the singlet oxygen generated upon irradiation of the encapsulated ZnPc killed the cells efficiently. These nanoparticles thus exhibit dual functionality as nanophotosensitizers for photodynamic therapy and as nanoplatforms for pH‐controlled drug release. More information can be found in the Full Paper by D. K. P. Ng, P.‐C. Lo et al. on page 16505. |
| doi_str_mv | 10.1002/chem.201704058 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0947-6539 |
| ispartof | Chemistry : a European journal, 2017-11, Vol.23 (65), p.16411-16411 |
| issn | 0947-6539 1521-3765 |
| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Cancer Chemistry Chemotherapy Doxorubicin Drug delivery systems Encapsulation Internalization Irradiation mesoporous silica nanoparticles Nanoparticles pH effects Photodynamic therapy phthalocyanines Porous materials Radiation Silica Silicon dioxide Singlet oxygen Synergistic effect Zinc |
| title | Cover Feature: Encapsulating pH‐Responsive Doxorubicin–Phthalocyanine Conjugates in Mesoporous Silica Nanoparticles for Combined Photodynamic Therapy and Controlled Chemotherapy (Chem. Eur. J. 65/2017) |
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